Biomedical Engineering: Innovations in Tissue Engineering

Biomedical engineering applies the engineering knowledge and technique in order to improve the medical field. Clearly one of its leading concepts is tissue engineering that focuses on growing new tissue to replace or support the compromised tissue(s).

Technological Advances: Tissue engineering involves creating functional tissues through deposition of a scaffold, cells and bioactive factors. Other top methods such as 3D bioprinting and stem cell treatment have advanced meaning that the formation of sophisticated tissue structures can be done. Tissue engineering is involved in regenerative medicine, for example; skin substitutes for patients with burn injuries, the repair or replacement of damaged cartilage and the creation and culture of organoids for disease research and pharmacological testing.

Challenges: This includes the need to develop means of providing the engineered tissues with new blood vessels, tissue rejection by the body’s immune system, and the enhancement of the technology for commercial production.

Future Directions: Current research aims at optimizing the scaffold composing materials and stem cell differentiation, applying the artificial intelligence to forecast the growth of tissues, etc. These should strive to be developed into functional organs for transplant so as to cut down on the sources of donor organs.

Conclusion: Tissue engineering is one of the rapidly burgeoning areas or sub-discipline of biomedical engineering which seeks to change the face of regenerative medicines and organ transplantation. Maintaining a close working relationship with health care’s other professions and continuously pushing the use of new technology is needed to overcome present limitations and attain clinical success.

Author: Neer Patel

References:

Langer R, Vacanti JP. Tissue engineering. Science. 1993 May 14;260(5110):920-926. doi:10.1126/science.8493529.

Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol. 2014 Aug;32(8):773-785. doi:10.1038/nbt.2958.

Cao Y, Vacanti JP, Paige KT, Upton J, Vacanti CA. Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear. Plast Reconstr Surg. 1997 Jul;100(2):297-302. doi:10.1097/00006534-199707000-00001.

Ingber DE. From cellular mechanotransduction to biologically inspired engineering. Annu Rev Biomed Eng. 2003;5:427-456. doi:10.1146/annurev.bioeng.5.011303.120700.

Previous
Previous

CRISPR Therapeutics: Pioneering Gene Editing

Next
Next

AI in Cancer Prognosis, Prediction, and Treatment Selection